Bimodal pore structure
The pore structure of a bone substitute is a critical parameter, governing the dynamic processes of vascularisation and osseointegration. Orthoss® Collagen has a bimodal pore size distribution of nanosize and macrosize pores which facilitate these dynamic processes. The macropores of Orthoss® Collagen offer an ideal environment for new bone formation.
Another attribute of Orthoss® Collagen, related to the nanosize pores, is its hydrophilic character. The hydrophilic nature leads to rapid fluid uptake and adhesion to the contact bony surface1, while cells are readily retained. Through this, Orthoss® Collagen distinguishes itself as an ideal carrier matrix,
also for use with bone marrow cell concentrate.
Exceptional osteoconductivity and osseointegration
Orthoss® Collagen is biocompatible with outstanding interfacial contact to the host bone.1,2 The granules are integrated into the surrounding bone and become part of the physiological remodeling process.3,4
The interconnected pore system and high porosity of Orthoss® Collagen result in an inner surface area which is significantly larger than that of other available bone graft substitutes. It is similar to that of autologous bone.
Since the inner surface area regulates the amount of blood, proteins and growth factors which can be absorbed, Orthoss® Collagen facilitates angiogenesis and the migration of osteoblasts. It also aids nutrient access and removal of metabolic waste products.
1. Rohner, D. et al. (2013). Int J Oral Maxillofac Surg. 42(5): 585-91.
2. Trevisiol, L. et al. (2012). J Craniofac Surg. 23(5): 1343-8.
3. Thaller, SR. (1994). J Craniofac Surg. 5(4): 242-6.
4. Orsini, G. et al. (2005). J Biomed Mater Res B Appl Biomater. 74(1): 448-57.